Table 1.

Top 35 hits from genome-wide CRISPR screen, determined by MAGeCK.

Gene IDPos | scorePos | P valuePos | FDRPos | rankPos | lfcRelated pathway
Ppox3.25E−162.52E−070.00024814.2704Heme
Alad1.18E−152.52E−070.00024825.071Heme
Pdxk1.53E−142.52E−070.00024834.2593Heme
Hmbs4.25E−142.52E−070.00024843.0221Heme
Cpox9.66E−132.52E−070.00024853.1179Heme
Apaf11.02E−122.52E−070.00024861.7716Apoptosis
Casp91.43E−122.52E−070.00024871.8948Apoptosis
Trp531.64E−122.52E−070.00024881.4796Apoptosis
Casp34.93E−122.52E−070.00024891.4571Apoptosis
Dffb9.85E−122.52E−070.000248101.5408Apoptosis
Glrx51.65E−112.52E−070.000248113.4678
Dffa1.91E−112.52E−070.000248121.4907Apoptosis
Ube2m3.83E−112.52E−070.000248131.4299
Alas12.62E−102.52E−070.000248142.9046Heme
Fech2.93E−092.52E−070.000248152.8039Heme
Cluh5.67E−092.52E−070.000248161.1662
Peo19.63E−092.52E−070.000248171.4576
Uros1.92E−082.52E−070.000248183.228Heme
Pnpo4.29E−082.52E−070.000248191.3911Heme
Eefsec5.42E−082.52E−070.000248201.7452
Cycs1.49E−077.55E−070.000646211.5336Apoptosis
Suclg11.50E−077.55E−070.000646221.1732Heme
Fam122a1.53E−077.55E−070.000646231.149
Elp53.06E−071.26E−060.001031241.3464
Xpo74.38E−071.76E−060.001386251.2388
Pcyt1a5.41E−072.26E−060.001714261.9908
Pstk8.82E−072.77E−060.001945271.084
Wbscr168.96E−072.77E−060.001945282.0637
Trub21.97E−066.29E−060.004268291.247
Ttc142.29E−067.80E−060.005105301.415
Hnrnpa2b12.51E−068.30E−060.005105311.2129
Mthfd22.57E−068.30E−060.005105321.0731
Lztr13.17E−061.18E−050.007051330.61398
Slc25a324.13E−061.48E−050.008591341.017
Ubp14.45E−061.64E−050.009194350.98916
  • Note: Pos | Score, the RRA value of the gene in positive selection; Pos | P value, raw P value of this gene in positive selection; Pos | FDR, FDR of this gene in positive selection; Pos | rank, ranking of each gene in positive selection; Pos | lfc, log fold change of the gene in positive selection; related pathway, category of gene as determined by Enrichr/GSEA.