Table 1.

Associations between GG or pathologic stage and genes with CNAs at higher frequency in AA/black than EA/white men.

Gleason gradeLocalized vs. locally advanced
N≤2 (n = 109)3 (n = 26)≥4 (n = 35)P (Spearman)≤T2 (n = 102)T3 (n = 69)ORP
LRP1B319 (8.3%)12 (46.2%)10 (28.6%)4.37E-0516 (15.7%)15 (21.7%)1.49 (0.68–3.27)0.32
MAP3K77237 (33.9%)10 (38.5%)25 (71.4%)4.83E-0433 (32.4%)39 (56.5%)2.72 (1.45–5.11)0.002
BNIP3L7838 (34.9%)19 (73.1%)21 (60.0%)3.37E-0434 (33.3%)45 (65.2%)3.75 (1.97–7.14)5.77E-05
MYC4117 (15.6%)9 (34.6%)15 (42.9%)3.28E-0417 (16.7%)25 (36.2%)2.84 (1.39–5.81)0.004
RB16025 (22.9%)12 (46.2%)23 (65.7%)1.08E-0625 (24.5%)36 (52.2%)3.36 (1.75–6.46)2.76E-04
THADA146 (5.5%)4 (15.4%)4 (11.4%)0.125 (4.9%)10 (14.5%)3.29 (1.07–10.09)0.037
NEIL3142 (1.8%)8 (30.8%)4 (11.4%)0.0014 (3.9%)10 (14.5%)4.15 (1.25–13.84)0.02
BUB1B164 (3.7%)6 (23.1%)6 (17.1%)0.0018 (7.8%)8 (11.6%)1.54 (0.55–4.32)0.41