Table 2.

Ingenuity canonical pathways of MSGE common to spontaneous models of metastasis.

−Log (P)
Nicotine degradation II6.98
Estrogen biosynthesis5.23
Acetone degradation I (to methylglyoxal)5.13
Bupropion degradation4.4
Agranulocyte adhesion and diapedesis3.94
Nicotine degradation III3.66
Hepatic fibrosis/hepatic stellate cell activation3.35
Atherosclerosis signaling3.23
Intrinsic prothrombin activation pathway3.04
Cellular effects of sildenafil (Viagra)2.91
Granulocyte adhesion and diapedesis2.88
  • Note: IPA results showing the pathways populated by MSGE common to both spontaneous allograft and GEMM models. Significance of enrichment for this pathway in each gene set is indicated by the −log(P) where >1.3 is significant.