Table 1.

Ingenuity canonical pathways of orthotopic versus tail vein allograft model MSGE.

4T1−Log (P)6D1−Log (P)Mvt1−Log (P)
Granulocyte adhesion and diapedesis9.25Th1 and Th2 activation pathway17.3Antigen presentation pathway7.19
Agranulocyte adhesion and diapedesis7.16Th1 pathway14.9Allograft rejection signaling5.79
Th1 and Th2 activation pathway7.14Th2 pathway14.2OX40 signaling pathway4
VDR/RXR activation6.89iCOS-iCOSL signaling in Th cells11.8Cytotoxic T lymphocyte–mediated apoptosis of target cells3.27
Th2 pathway6.83Altered T cell and B cell signaling in rheumatoid arthritis11.5Cdc42 signaling3.21
Th cell differentiation6.2Granulocyte adhesion and diapedesis11.3Graft-versus-host disease signaling2.97
LXR/RXR activation4.97Type I diabetes mellitus signaling11Autoimmune thyroid disease signaling2.95
Th1 pathway4.97CD28 signaling in Th cells10.9Protein ubiquitination pathway2.59
iCOS-iCOSL signaling in Th cells4.54Th cell differentiation10.8Cross-talk between dendritic cells and natural killer cells2.44
Nur77 signaling in T lymphocytes4.09Dendritic cell maturation10.4Systemic lupus erythematosus in T-cell signaling pathway2.35
  • Note: IPA results showing the top 10 significantly enriched pathways by orthotopic-specific MSGE of 4T1, 6DT1, and Mvt1. Significance of enrichment for this pathway in each gene set is indicated by the −log(P) where >1.3 is significant.