Table 1.

Combination study summary table.

SH-4-54 and 27HC comb.Adjusted PCDI valueCombination effect
24-h time point
 Control vs. 27HC0.9955
 Control vs. 2.5 μmol/L0.9857
 Control vs. 5 μmol/L>0.9999
 Control vs. 10 μmol/L<0.0001
 2.5 μmol/L vs. 2.5 μmol/L + 27HC0.82851.03Antagonistic
 5 μmol/L vs. 5 μmol/L + 27HC<0.00010.60Significantly synergistic
 10 μmol/L vs. 10 μmol/L + 27HC0.89340.92Synergism
48-h time point
 Control vs. 27HC<0.0001
 Control vs. 2.5 μmol/L>0.9999
 Control vs. 5 μmol/L0.5826
 Control vs. 10 μmol/L<0.0001
 2.5 μmol/L vs. 2.5 μmol/L + 27HC<0.00011.02Antagonistic
 5 μmol/L vs. 5 μmol/L + 27HC<0.00010.53Significantly synergistic
 10 μmol/L vs. 10 μmol/L + 27HC0.0010.89Synergism
72-h time point
 Control vs. 27HC<0.0001
 Control vs. 2.5 μmol/L0.946
 Control vs. 5 μmol/L0.0006
 Control vs. 10 μmol/L<0.0001
 2.5 μmol/L vs. 2.5 μmol/L + 27HC<0.00011.04Antagonistic
 5 μmol/L vs. 5 μmol/L + 27HC<0.00010.54Significantly synergistic
 10 μmol/L vs. 10 μmol/L + 27HC<0.00010.72Synergism
C188-9 and 27HC comb.Adjusted PCDI valueCombination effect
24-h time point
 Control vs. 27HC0.5282
 Control vs. 10 μmol/L0.7551
 Control vs. 20 μmol/L0.2687
 Control vs. 40 μmol/L<0.0001
 10 μmol/L vs. 10 μmol/L + 27HC0.1670.85Synergism
 20 μmol/L vs. 20 μmol/L + 27HC<0.00010.86Synergism
 40 μmol/L vs. 40 μmol/L + 27HC0.1670.91Synergism
48-h time point
 Control vs. 27HC<0.0001
 Control vs. 10 μmol/L0.4243
 Control vs. 20 μmol/L<0.0001
 Control vs. 40 μmol/L<0.0001
 10 μmol/L vs. 10 μmol/L + 27HC<0.00010.77Synergism
 20 μmol/L vs. 20 μmol/L + 27HC<0.00010.67Significantly synergistic
 40 μmol/L vs. 40 μmol/L + 27HC<0.00010.78Synergism
72-h time point
 Control vs. 27HC<0.0001
 Control vs. 10 μmol/L0.0339
 Control vs. 20 μmol/L<0.0001
 Control vs. 40 μmol/L<0.0001
 10 μmol/L vs. 10 μmol/L + 27HC<0.00010.72Synergism
 20 μmol/L vs. 20 μmol/L + 27HC<0.00010.61Significantly synergistic
 40 μmol/L vs. 40 μmol/L + 27HC<0.00010.83Synergism