Table 1.

Different DSB repair pathway proteins and their associated inhibitors.

DSB repair proteinsDSB repair pathwayInhibitorsReferences
PARPAlt-NHEJOlaparib, niraparib, rucaparib, veliparib (ABT-888), talazoparib (BMN-673)PMID: 28003236
ATMSignaling (kinase targets: CHK2, H2AX, NF-κB, AKT, p53,IGF-1R)KU5593, KU60019, CP466722, AZ32, AZD8055, NU7026, VE-821PMID: 31299316, 22079189
CHK2EffectorsPrexasertib (LY2606368), Chk2 inhibitor II (BML-277)PMID: 27308506
MRE11Damage sensors, resectionMirinPMID: 29523233
DNA-PKcsNHEJ (kinase targets: CHK2, H2AX, p53, Artemis, Ligase IV)NU7441 (KU-57788), NU7026, LTURM34, CC-115PMID: 28820390
Rad51HRRI-1, RS-1, B02PMID: 24856061
Ligase IVNHEJSCR7PMID: 23260137