Table 1.

The role of YAP/TAZ in immune cells

ImmuneCell effectReferences
Th17 cellTAZ- but not YAP-derived Th17 cells differentiation by activating RORγt.65
TregTAZ inhibited the differentiation of Treg by suppressing Foxp3 expression.65
TAZ was dispensable for T-cell activation and proliferation.65
YAP determined Treg differentiation by promoting the signaling down the TGFβ/SMAD axis, leading to the promotion of melanoma.70
YAP-1 was found to promote Treg differentiation by upregulating the TGFBR2 expression, inducing the immunosuppression in HCC.72
CD8+ T cellYAP 5SA suppressed CD8+ T-cell differentiation by inhibiting the transcription of Blimp-166
B cellYAP participated in the regulation of B-cell differentiation and function by activating TEAD2-mediated BCR signaling reduction.78, 105
YAP phosphorylation and interaction with Hck prevented B-cell death by downregulating the expression of proapoptotic molecule NLRC4.79, 107
MacrophageYAP1 deficiency significantly inhibited osteoclast differentiation and function by impairing AP-1 transcriptional activity and RANKL-induced NF-κB signaling.91
TAZ regulated L. pneumophilam maximal intracellular replication and infection by manipulating PPARγ expression.87
TAZ also could modulate the polarization and inflammatory responses of macrophages by regulating the transcription of PPARγ.87
YAP could promote the migration of M1-like macrophages in vitro and in vivo in HCC by SPON2-integrin α4β1-RhoA signaling–mediated F-actin accumulation.94