Table 3.

Summary of mouse model subtyping results in comparison with respective HCC patient subsets (TCGA)

ModelEtiology-based CGH/syntenyG1–6 groups CGH/syntenyHistologic featuresIHC profilesImmune infiltrationInter-/intratumor heterogeneity
DENAlcohol-inducedG3/G5Inclusion bodies, fibrosis (in tumors), steatosisOnly stem/biliary-like phenotypesScarceNo/No
c-MycAlcohol-inducedG5Pleomorphism, clear cell fociWNT activationModerateYes/No
AlbLTαβNASH-associatedG3Fatty change, steatosis, massive lymphocyte infiltrationStem/biliary-like >WNT activationSevereYes/Yes
TAK1LPC-KONASH-associatedG3/G5Signs of liver injury (eosinophilic change)No WNT activation No Stem/biliary-likeScarceNo/No
Mcl-1ΔhepViral hepatitisG3Highly proliferative, steatosis, fatty change, lymphocyte infiltrationStem/biliary-like>>WNT activationModerateYes/Yes