Table 2.

A microarray analysis–based comparison of TP53-mutant and TP53WT cells

WT vs. E10Fold change ≧ 5.0
TP53WTTP53E10TP53E10/WT
Gene nameNormalizedNormalizedFold change
REG1B0.0110.46774.54
REG1A1.63716.66439.75
ENST000005659010.011.6158.85
CCR20.6110.1916.83
DACH10.616.9111.35
VCAN0.241.87.51
CCR50.463.236.99
CDH110.643.475.43
HOXA30.231.185.03
WT vs. E3Fold change ≧ 5.0
TP53WTTP53E3TP53E3/WT
Gene nameNormalizedNormalizedFold change
None
Fold change ≧ 5.0
E3 vs. E10TP53E3TP53E10TP53E10/E3
Gene nameNormalizedNormalizedFold change
REG1B0.0310.46318.39
REG1A3.95716.66181.22
ENST000005659010.011.6139.47
HOXB80.042.3362.23
CD700.229.1641.19
CLDN10.081.2917.07
PDZD20.334.5913.82
HOXB91.2917.3713.49
UGT2B150.141.6111.3
ANGPT10.242.229.15
LOC1019274970.171.468.71
HOXA30.141.188.25
TP530.292.217.53
DACH10.332.437.36
CDH110.543.476.45
PRDM80.553.486.31
DACH11.26.915.74
THBS40.73.75.28
  • NOTE: A microarray analysis revealed genes upregulated by more than 5-fold in TP53E10 cells relative to TP53WT cells (top table), no such genes were detected in TP53E3 cells relative to TP53WT cells (middle table). We also assessed genes upregulated by more than 5-fold in TP53E10 cells relative to TP53E3 cells (bottom table). Only the top three genes in TP53E10 were upregulated relative to both TP53E3 and TP53WT.