Table 1.

List of variables that are known to be associated with differences in survival in lower grade glioma patients

CovariateMedian (min–max) or number of patients
Age41 (14–87)
GenderFemale250
Male200
Somatic mutation count50 (0–12255)
Percent aneuploidy11% (5.2E-4%–95%)
log(TERT Expression)1.0 (0.0–9.1) FPKM
Principal component 1 (PC1)0.043 (−0.091–0.064)
Principal component 2 (PC2)−0.017 (−0.23–0.17)
Principal component 3 (PC3)−0.53 (1.34E-4–0.33)
Histologic typeAstroctyoma172
Oligoastrocytoma113
Oligodendroglioma165
Tumor locationFrontal lobe265
Temporal lobe125
Parietal lobe42
Other18
GradeG2212
G3237
Cannot be assessed1
Treatment siteHenry Fords Hospital82
Case Western St. Joseph Hospital90
Other278
IDH MutantWild type83
Mutant367
1p/19q CodeletionAbsent303
Present147
MGMT Promoter methylationUnmethylated80
Methylated370
Chr 7 gain/Chr 10 lossAbsent399
Present51
TP53 MutantAbsent232
Present218
  • NOTE: Eleven variables (bolded) were selected by Lasso for inclusion in the survival model. We used these 11 variables as covariates in our Cox regression model when testing each germline variant.