Table 2.

IC50 values (μmol/L) against osimertinib with crizotinib in MET-amplified osimertinib-resistant cell lines

EGFR-TKIMET Inhibitor
Cell linesOsimertinibCrizotinibOsimertinib with crizotinib (0.2 μmol/L)
HCC827-ORH4.94.54.4
PC9-ORH3.52.32.2
HCC4011-ORH5.34.40.042