Table 1.

Osimertinib-resistant cell lines and resistant mechanisms

Cell lineOsimertinib exposureEGFR MutationOsimertinib IC50 (╬╝mol/L)T790M MutationC797S MutationMET AmplificationEMT PhenotypesAXL Upregulation
HCC827 ParentalN/A0.019--
HCC827-ORSStepwise19 Del3.9---++
HCC827-ORHHigh4.9--++-
HCC4006 ParentalN/A0.022--
HCC4006-ORSStepwise19 Del4.6---++
HCC4006-ORHHigh4.6---++
PC9 ParentalN/A0.036--
PC9-ORSStepwise19 Del3.9----+
PC9-ORHHigh3.9--+-+
H1975 ParentalN/AL858R0.036+-
H1975-ORSStepwise+5.2+--++
H1975-ORHHighT790M5.2+--++
HCC4011 ParentalN/AL858R0.031--
HCC4011-ORHHigh5.3--+--
  • Abbreviations: EMT, epithelial to mesenchymal transition; N/A, not applicable