Table 1.

TP53 mutations in AACR Project GENIE registry v3.0.0

Non-lung cancers n = 33,011 samplesAdenocarcinoma n = 5,060 samplesSquamous cell lung cancer n = 559 samplesSmall cell lung cancer (SCLC) n = 236 samples
TP53 mutationsa13,080 mutations in 11,983 samples (36.3%)2,513 mutations in 2,333 samples (46.1%)479 mutations in 438 samples (78.4%)190 mutations in 184 samples (78.0%)
TP53 missense mutations8,8131,750297112
Traditional TP53 hotspot missense mutationsb
 R273951 (10.8%)117 (6.7%)16 (5.4%)8 (7.1%)
 R248847 (9.6%)106 (6.1%)22 (7.4%)4 (3.6%)
 R175736 (8.4%)44 (2.5%)7 (2.4%)4 (3.6%)
 G245324 (3.7%)68 (3.9%)10 (3.4%)3 (2.7%)
Lung-enriched TP53 hotspot missense mutationsb
 R15887 (1.0%)73c (4.2%)22 (7.4%)6 (5.4%)
 V15767 (0.8%)49c (2.8%)9 (3.0%)5 (4.5%)
 A15948 (0.5%)25c (1.4%)4 (1.3%)0 (0%)
  • aFrequency is represented in percent of samples with TP53 mutations (including missense, truncating, inframe, and other mutations) out of total number of samples for each histologic subtype.

  • bFrequency is represented in percent of missense mutations out of total number of missense mutations for each histologic subtype.

  • cOne case had V157F and A159 mutations (counted separately), and one case had R158L and R158C mutations (counted separately).