Table 1.

Patient characteristics of the 73 pediatric ALL patients

CharacteristicsN, %
Number of cases73
ALL subtype
 Pre-B ALL57 (78)
 T-ALL16 (22)
Age, y, median (range)7.3 (0.2–18.0)
Gender
 Male40 (55)
 Female33 (45)
Declared Ethnicity
 Caucasian61 (84)
  Hispanic44 (72)
  Non-Hispanic17 (28)
 Black American6 (8)
 Asian4 (5)
 Mixed2 (3)
 Other1 (1)
"SNP" Ethnicity
 European9 (12)
 African6 (8)
 Hispanic/American Indian38 (52)
 Asian1 (1)
 Not done19 (26)
Cytogenetics
 Favorable15 (21)
 Intermediate42 (58)
 Unfavorable15 (21)
 Unknown1 (1)
Risk group
 Low risk4 (5)
 Standard/intermediate risk29 (40)
 High/very high risk40 (55)
CNS status
 CNS-146 (63)
 CNS-220 (27)
 CNS-36 (8)
 Unknown2 (3)
Response
 Complete remission67 (92)
 Resistant4 (5)
 Fail2 (3)
Alive63 (86)
  • NOTE: Cytogenetic aberrations were classified into favorable, intermediate, and unfavorable cytogenetics. Favorable: hyperdiploid, diploid and t(12:21) EVT6/RUNX1 translocation; unfavorable: 11q23 rearrangement, hypodiploid, t(9;22) BCR/ABL1 translocation, 5q deletion. Patients that were not classified as favorable or unfavorable were defined as having intermediate cytogenetics. Central nervous system (CNS) involvement was categorized into three groups according to the COG standard. CNS-1: no blasts in the cerebrospinal fluid (CSF), CNS-2: <5% blasts in the CSF with or without red blood cells, CNS-3: >5% blasts in CFS. Risk group stratification was done according to the AALL protocols.