Table 2.

Demographics and laboratory features for 7 identified protein expression signatures

TotalProtein expression signature
CategoryTypeCountFreq.1234567P
Total (%)73100122719111685
ALL type (%)Pre-B57780758389100100100<0.001
T1622100251711000
White blood cell count (x k/μL)Median30.5397591181221667<0.001
Peripheral blood absolute blast (k/μL)Median25.13194199912561<0.001
Peripheral blast (%)Median73.9867083535778300.006
Lactate dehydrogenase (x U/L)Median2,0699,9144,7023,6092,0491,1951,500965<0.001
Bilirubin (mg/dL)Median0.30.60.30.20.50.20.20.40.004
Fibrinogen (mg/dlL)Median3321913302674954103603980.001
Human Leucocyte Antigen - antigen D-related (%)Median100098.510010010097.5100<0.001
Cytogenetics (%)Favorable15210140115015750.003
Intermediate4258925767782955250.021
Risk group (%)Intermediate121667131707025<0.001
CDKN2A mutation (%)Yes202175142511332200.025
  • NOTE: Significant patient characteristics and ALL features are shown for the overall patient cohort as well as for each protein expression signature. Other nonsignificant variables that were checked, but which lacked association with the protein expression signatures included: age at diagnosis, sex, race, CNS status, infection, IgH gene rearrangement, TCF3 gene rearrangement, ETV6 mutation, RUNX1 mutation, the percentage of bone marrow blasts, bone marrow and peripheral blood monocytes or promyelocytes, hemoglobin, platelet count, albumin and creatinine. P values were generated using the Kruskal–Wallis test by ranks for continuous variables and the Fisher exact test for categorical variables.