Table 2.

Multivariate Cox PH analysis of HRD as a predictor of PFS and OS

PFSOS
VariableLevelsPatients N (%)HR (95% CI)PHR (95% CI)P
All patients
HRD statusHRD positive71 (31)0.44 (0.30–0.65)2.1 × 10−50.45 (0.27–0.74)0.0012
HRD negative155 (69)RefRef
Age at surgeryYears226 (100)1.01 (0.99–1.02)0.551.00 (0.98–1.03)0.68
HistologySerousa/clear cell189 (84)1.34 (0.72–2.49)0.341.18 (0.53–2.63)0.68
Other37 (16)RefRef
GradeLow20 (9)Ref0.013Ref0.0064
High206 (91)2.59 (1.11–6.05)4.70 (1.13–19.51)
StageIC–II56 (25)Ref0.00014Ref0.12
III144 (64)3.33 (1.80–6.16)1.84 (0.84–4.05)
IV26 (12)2.37 (1.12–4.98)1.13 (0.42–3.05)
Bulk of residual diseaseNone/microscopic85 (38)Ref0.0049Ref0.091
Macroscopic <2 cm54 (24)1.35 (0.80–2.30)1.41 (0.69–2.86)
Macroscopic >2 cm87 (38)2.04 (1.28–3.24)1.92 (1.03–3.61)
Performance status069 (31)Ref0.19Ref0.17
1122 (54)1.17 (0.75–1.84)1.02 (0.57–1.83)
235 (15)1.66 (0.94–2.92)1.73 (0.85–3.56)
HGSOC
HRD statusHRD positive63 (36)0.46 (0.30–0.70)2.2 × 10−40.47 (0.28–0.81)0.0048
HRD negative110 (64)RefRef
Age at surgeryYears173 (100)1.01 (0.99–1.03)0.391.02 (0.99–1.04)0.19
StageIC–II31 (18)Ref0.019Ref0.12
III120 (69)2.12 (1.07–4.20)1.59 (0.63–4.00)
IV22 (13)1.28 (0.56–2.90)0.78 (0.25–2.49)
Bulk of residual diseaseNone/microscopic49 (28)Ref0.0055Ref0.32
Macroscopic <2 cm48 (28)1.37 (0.77–2.44)1.11 (0.52–2.36)
Macroscopic >2 cm76 (44)2.15 (1.28–3.60)1.54 (0.78–3.03)
Performance status041 (24)Ref0.083Ref0.18
1100 (58)1.27 (0.75–2.15)1.13 (0.56–2.30)
232 (18)1.98 (1.05–3.75)1.91 (0.83–4.38)
  • aOne patient with serous or endometrioid histology was categorized as serous for this analysis.