Table 3.

Multivariate Cox PH analysis of CCNE1 as a predictor of PFS and OS

PFSOS
VariableLevelsHR (95% CI)PHR (95% CI)P
Overall cohort (N = 225)
CCNE1 statusAmplified2.19 (1.49–3.22)1.8 × 10−41.63 (1.01–2.63)0.052
Not amplifiedRefRef
Age at surgeryYears1.02 (1.00–1.03)0.0511.02 (0.99–1.04)0.15
HistologySerousa/clear cell1.31 (0.71–2.43)0.371.18 (0.53–2.62)0.68
OtherRefRef
GradeLowRef0.072Ref0.020
High2.03 (0.87–4.73)3.89 (0.94–16.1)
StageIC–IIRef7.9 × 10−5Ref0.17
III3.35 (1.86–6.03)1.77 (0.83–3.80)
IV2.57 (1.25–5.29)1.17 (0.44–3.08)
Bulk of residual diseaseNone/microscopicRef0.0036Ref0.099
Macroscopic ≤2 cm1.10 (0.66–1.83)1.19 (0.59–2.38)
Macroscopic >2 cm1.91 (1.21–3.04)1.81 (0.96–3.38)
Performance status0Ref0.48Ref0.28
11.06 (0.68–1.65)0.92 (0.51–1.65)
21.37 (0.78–2.42)1.45 (0.71–2.99)
HGSOC subset (N = 172)
CCNE1 statusAmplified1.95 (1.28–2.99)0.00331.69 (1.01–2.84)0.056
Not amplifiedRefRef
Age at surgeryYears1.02 (1.00–1.04)0.0191.03 (1.00–1.06)0.018
StageIC–IIRef0.010Ref0.13
III2.45 (1.26–4.75)1.71 (0.70–4.20)
IV1.61 (0.73–3.57)0.89 (0.29–2.75)
Bulk of residual diseaseNone/microscopicRef0.0031Ref0.25
Macroscopic ≤2 cm1.07 (0.61–1.87)0.94 (0.45–1.97)
Macroscopic >2 cm1.99 (1.19–3.30)1.45 (0.74–2.85)
Performance status0Ref0.29Ref0.36
11.12 (0.67–1.88)0.99 (0.49–2.01)
21.58 (0.84–2.97)1.52 (0.66–3.51)