Table 2.

Association of proximal ACF with synchronous neoplasia in participants

Synchronous neoplasiaNo proximal ACF (n = 103)At least one proximal ACF (n = 67)P
Any
Number of cases (%)44 (42.7)49 (73.1)
Sex and age-adjusted OR (95% CI)1 (referent)3.58 (1.84–7.00)<0.001
Multivariable OR (95% CI)a1 (referent)3.28 (1.62–6.64)0.001
Traditional adenoma
Number of cases (%)25 (24.3)31 (46.3)
Sex and age-adjusted OR (95% CI)1 (referent)2.67 (1.38–5.18)0.004
Multivariable OR (95% CI)b1 (referent)2.66 (1.32–5.36)0.006
Serrated polyp
Number of cases (%)22 (21.4)24 (35.8)
Sex and age adjusted OR (95% CI)1 (referent)1.26 (0.66–2.39)0.480
Multivariable OR (95% CI)b1 (referent)1.62 (0.76–3.49)0.214
Distal colon polyp
Number of cases (%)22 (21.4)23 (34.3)
Sex and age-adjusted OR (95% CI)1 (referent)1.93 (0.96–3.88)0.063
Multivariable OR (95% CI)b1 (referent)1.50 (0.69–3.24)0.305
Proximal colon polyp
Number of cases (%)29 (28.2)35 (52.2)
Sex and age-adjusted OR (95% CI)1 (referent)2.76 (1.44–5.29)0.002
Multivariable OR (95% CI)b1 (referent)2.54 (1.25–5.19)0.010
Proximal traditional adenoma
Number of cases (%)13 (12.6)20 (29.9)
Sex and age-adjusted OR (95% CI)1 (referent)3.02 (1.34–6.82)0.008
Multivariable OR (95% CI)b1 (referent)2.69 (1.12–6.47)0.027
Proximal serrated polyp
Number of cases (%)14 (13.6)13 (19.4)
Sex and age-adjusted OR (95% CI)1 (referent)1.53 (0.67–3.52)0.314
Multivariable OR (95% CI)b1 (referent)1.69 (0.67–4.27)0.265
  • aLogistic regression models adjusted for age, sex, smoking status, BMI (<25 vs. 25–30 vs. ≥30 kg/m2), screening history, regular aspirin use (at least once/week), multivitamin use (at least once/week), and endoscopic counts of distal ACF.

  • bLogistic models adjusted for the covariates denoted by (a) and the presence of the other synchronous lesion subtype, e.g., when traditional adenoma is modeled as the outcome, presence of a serrated adenoma is included as a covariate and vice versa.