Table 2.

Experimental and predicted genes ranked by multiple robustness metrics

Experimental genesSensitivity1−SpecificityNormalized closenessAggregate scorePredicted genesSensitivity1-SpecificityNormalized closenessAggregate score
LCK0.000.8910.9200.963BCL20.000.9010.9640.975
RAF10.000.7231.0000.956RAF1_S4990.000.9500.8760.961
PHKA20.000.9410.7800.936BCL2_S700.000.9700.8490.958
PIN10.000.8710.8210.935XIAP0.000.9500.8510.955
PRKCA0.000.7130.9230.935CASP90.000.9410.8350.950
PTPRM0.000.9210.7300.921CASP30.000.9310.8210.945
PPP3CA0.000.8510.7740.920CASP9_S1830.000.9600.7990.944
BLK0.000.8610.7580.918BCL2_Ser870.000.9500.7950.941
SH2D1A0.000.8510.7380.911PIN1_S160.000.9410.7860.938
PTPN220.000.8320.7320.907SLAMF1_Y3070.000.9900.7380.933
ABL10.000.9010.6680.902NR1I3_T380.000.9900.7360.933
NR1I30.000.9600.6090.897PTBP1_S160.000.9700.7360.930
RXRB0.000.9110.6350.895LCK_Tyr3940.000.9700.7320.929
GMFB0.000.9500.6090.895VASP_S1570.000.9500.7390.928
PIM10.000.8810.6540.895TRPV5_S6540.000.9500.7360.927
PPP2CB0.000.8420.6730.894CASP9_Y1530.000.9900.6880.921
PTBP10.000.9010.6090.887PIN1_S1380.000.9500.6700.910
TRPV50.000.8910.6090.886WNK30.000.9500.6670.909
IRAK10.000.9110.5870.883CDC25A_Ser116Ser3210.000.9310.6560.904
CKS20.000.8810.5630.873TAB10.000.8420.7030.901
CDC14A0.000.8910.5540.872TSC22D40.000.8710.6700.898
DUSP50.000.8910.5540.872VASP0.000.9410.6140.895
TRPM70.000.9110.5400.872SLAMF10.000.8910.6160.887
CDC25A0.000.5050.8010.872PPP4C0.000.8810.5720.875
MAP3K110.000.8710.5630.871SH2D1B0.000.8910.5250.865
WWP20.000.9310.5240.871PTEN0.000.6830.6560.864
PPEF20.000.9500.5090.870EEF2K_S780.000.9500.4700.861
PPEF10.000.9410.5090.869SIK2_T1750.000.9210.4420.849
PPP2R1A0.000.8220.5740.866SNRK_T1730.000.9110.4410.847
ERBB40.000.8020.5620.860TP53_S150.000.6440.4430.805
OBSCN0.000.8810.5090.859STK110.000.5350.5030.803
AKAP110.000.8910.4970.858LCK_S420.990.9900.8420.373
CALM10.000.7330.5940.857PTEN_Y2400.990.9700.7680.351
PPP5C0.000.8910.4890.856MYH9_S19160.990.9800.7510.348
PPP4R10.000.8810.4930.855GMFB_S720.990.9800.7360.345
PPP1R12B0.000.8710.4970.855CASP9_Thr1250.990.9600.6850.329
SNRK0.000.9110.4410.847MYH90.990.9800.6300.318
PPFIA10.000.8020.4970.844MAPT_Ser198Ser199Ser202Thr205Thr212Ser214Ser235Ser262Ser396Ser404Ser4090.990.9500.5680.298
EEF2K0.000.8510.4150.831MYH9_T18000.990.9900.5380.297
SIK20.000.8710.3930.829PTEN_T3830.990.9210.5710.294
EGLN10.000.8510.3900.825MAPK3_na0.990.7820.6560.293
TP53RK0.000.8220.3940.821ING40.990.9600.4380.268
SMG10.000.8020.3940.818PPP1CB0.990.7230.5790.265
  • NOTE: Experimental genes (left) and predicted genes (right) were ranked by the following metrics: sensitivity represents fractional representation in a family of 100 networks created with 0.5% noise added to the interactome edges; specificity represents the fractional representation in a family of 100 networks created with random inputs and 1−specificity is used for ranking as low specificity indicates robustness to this type of randomization; normalized closeness centrality reflects a node's robustness as this metric indicates association to other nodes within the network; aggregate score was calculated by weighting each metric by the SD for that metric and normalizing to the maximum score possible for all experimental/predicted genes.