Table 2.

Number of mutations for selected TGFβ pathway components within low, medium and high TES groups

Absolute frequency of mutations within cell lines (number expected to cause protein sequence changes)
Selected genes from TGFβ pathwayLow TESMed TESHigh TES
TGFB13 (3)
TGFB226 (1)25 (3)16 (1)
TGFB36 (5)2 (1)
TGFBR117 (16)1 (0)
TGFBR224 (24)6 (4)1 (1)
SMAD26 (6)2 (1)1 (1)
SMAD35 (5)2 (1)1 (0)
SMAD421 (20)1 (1)
SMAD710 (3)2 (1)1 (0)
RHOA17 (15)2 (2)1 (1)
Relative frequency of TGFβ pathway mutations within cell line groups
Number of genes mutated in TGFβ pathway403328
Total mutations in TGFβ pathway genes466 (316) (n = 104 CLs)228 (268) (n = 104 CLs)135 (42) (n = 104 CLs)
Average TGFβ pathway mutations per cell line4.482.201.29
Total mutations19,01210,6077,626
  • Abbreviation: CL, cell lines.