Table 2.

List of oncogenic mutations identified in quadruple WT GIST samples

IDGenecDNAProteinPositionTumor ratioSomatic/germline
GIST127CTNND2c.2986_2987delinsAG>Tp.S996delinsWchr5:110228930,31Somatic
GIST257TP53a,bc.473G>Tp.R158Lchr17:75784570,40Somatic
TP53ac.680delCp.S227fs*18chr17:75776010,27Somatic
GIST268MAXac.100_110delTCCCTACGTTTp.K34fs*31chr14:655604870,29Somatic
NF1ac.G7781Tp.R2594Lchr17:296840200,41Germline
GIST279NF1ac.C4120Tp.H1374Ychr17:295799650,44Germline
GIST320MEN1a,bc.249_252delAGACp.L83fs*34chr11:645773300,93Somatic
TP53a,bc.646G>Ap.V216Mchr17:75782030,65Somatic
GIST401CHD4ac.2659delCp.R887fs*14chr12:67019770,47Somatic
GIST409FGFR1a,bc.1638C>Ap.N546Kchr8:382748490,59Somatic
  • aGene included in the Cancer Gene Census list.

  • bSame mutation presents in the COSMIC database.