Table 1.

Overall survival analysis in TCGA glioblastoma cohort.

Univariate analysis (n = 275)Multivariate analysis (n = 275)
FactorHR (95% CI)Significance levelHR (95% CI)Significance level
ESTIMATE tumor purity (continuous)0.30 (0.12–0.76) P = 0.012 0.28 (0.10–0.75) P = 0.011
MGMT status (methylated vs. unmethylated)0.74 (0.56–0.99) P = 0.043 0.78 (0.58–1.04) P = 0.088
Age (years)1.04 (1.03–1.05) P < 10−9 1.04 (1.03–1.05) P < 10−8
  • NOTE: Information on overall survival, tumor purity, MGMT status, and age was available for n = 275 IDH1 wild-type cases from the 2013 TCGA GBM cohort. A Cox proportional hazards model was fit for both univariate and multivariate analysis. Tumor purity was computed from cDNA microarray gene expression data using ESTIMATE. Bold font indicates a significance level of P < 0.05.

  • Abbreviation: 95% CI, 95% confidence interval.