Table 2.

Summary of integration events in HPV16-positive responsive and recurrent tumors

Cellular
TumorHPV siteLocusGeneGene nameRegionDomain
1733(F)E22p16Intergenic
1769(F)E29q21Intergenic
(R)L116q11.2Intergenic
(R)L14q27Intergenic
1804(R)E16q16Intergenic
(F)L210p11.1Intergenic
(F)E516q11.2Intergenic
(F)E216q11.2Intergenic
1971(F)E17p22.3Intergenic
(R)L24p16.3Intergenic
(R)L13q28TP63Tumor protein p63Intron 4DNA-binding domain
2148(F)L27p22Intergenic
2049(R)E18q11.21UBE2V2Ubiquitin-conjugating enzyme E2Intron 1Ubiquitin-conjugating domain
(R)E114q24.1SMOC1SPARC-related modular calcium binding 1Intron 1Kazal-like domain
0843(F)L22q24.3SCN2ASodium channel, voltage-gated, type II, α subunitIntron 16Helical transmembrane S6 of repeat II region
2238(R)L11p31.3-p31.2NFIANuclear factor I/AIntron 9DNA-binding domain
(R)E215q21.1SEMA6DSemaphorin 6DIntron 4Extracellular topological Sema domain
0732(R)E210p11.1Intergenic
(R)L217p11.2TNFRSF13BTNF receptor superfamily, 13BIntron 3Extracellular topological domain
1040(R)L210p11.1Intergenic
(R)L116p11.2SH2B1SH2B adapter protein 1Intron 3Plekstrin homology domain
  • NOTE: Locus of integration into the cellular genome are shown on the right side of the table. Responsive tumors (top five tumors) are 1733, 1769, 1804, 1971, and 2148. Recurrent tumors (bottom five) are 0732, 0843, 1040, 2049, and 2238, indicated in bold text.

  • Abbreviations: F, forward viral orientation in relation to the cellular gene; R, reverse viral orientation in relation to the cellular gene.