Table 1.

TTR, TCR, and rate of CRs to endocrine treatment ± AP-1 inhibition in xenografts of MCF7 Tet-off DN-cJun clones 62 and 67

nMedian TTRa (days)95% CIPMedian TCRb (days)95% CIP% CR at day 100c95% CI
TamClone 62Control (+DOX)155635–1400.014NA91–NA0.001207–50
DN-cJun (−DOX)113521–429149–11272.746.1–93.7
Clone 67Control (+DOX)17NA56–NA0.006NANA0.00300–0
DN-cJun (−DOX)174935–6311291–NA33.315.4–62.5
EDClone 62Control (+DOX)149456–1400.0006NA182–NA<0.000100–0
DN-cJun (−DOX)143528–3566.542–8485.763.4–97.7
Clone 67Control (+DOX)174228–630.0687756–1890.70464.743–85.5
DN-cJun (−DOX)182828–358463–13361.140–82.5
  • Abbreviations: CI, confidence interval; DOX, doxycycline; ED, estrogen deprivation; Tam, tamoxifen.

  • aTTR: time to response (time elapsed from randomization to tumor size halving).

  • bTCR: time to complete response (time elapsed from randomization to tumor disappearance).

  • c% CR: percent of mice with complete response at day 100 (no palpable tumor for two consecutive measurements).