Table 1.

TTR, TCR, and rate of CRs to endocrine treatment ± AP-1 inhibition in xenografts of MCF7 Tet-off DN-cJun clones 62 and 67

			n	Median TTR^a (days)	95% CI	P	Median TCR^b (days)	95% CI	P	% CR at day 100^c	95% CI
Tam	Clone 62	Control (+DOX)	15	56	35–140	0.014	NA	91–NA	0.001	20	7–50
		DN-cJun (−DOX)	11	35	21–42		91	49–112		72.7	46.1–93.7
	Clone 67	Control (+DOX)	17	NA	56–NA	0.006	NA	NA	0.003	0	0–0
		DN-cJun (−DOX)	17	49	35–63		112	91–NA		33.3	15.4–62.5
ED	Clone 62	Control (+DOX)	14	94	56–140	0.0006	NA	182–NA	<0.0001	0	0–0
		DN-cJun (−DOX)	14	35	28–35		66.5	42–84		85.7	63.4–97.7
	Clone 67	Control (+DOX)	17	42	28–63	0.068	77	56–189	0.704	64.7	43–85.5
		DN-cJun (−DOX)	18	28	28–35		84	63–133		61.1	40–82.5

Abbreviations: CI, confidence interval; DOX, doxycycline; ED, estrogen deprivation; Tam, tamoxifen.
↵^aTTR: time to response (time elapsed from randomization to tumor size halving).
↵^bTCR: time to complete response (time elapsed from randomization to tumor disappearance).
↵^c% CR: percent of mice with complete response at day 100 (no palpable tumor for two consecutive measurements).