Table 1.

Effect of kinase inhibitors on NKX3.1 half-life

IC50—nmol/LTargetμmol/LT1/2
DMSO24.7
Compound A68DYRK1B0.1031.6
0.5046.9
DMSO24.7
NCGC0018598125DYRK1B0.1051.0
0.50≫50
DMSO28.0
NCGC001859631510DYRK1B0.50>50
2.0040.0
DMSO28.0
NCGC00185976103DYRK1B0.5066.0
2.0034.8
DMSO28
396213600MARK25.0033.5
10.0060.5
20.0042.0
DMSO26.0
NCGC0018598472DYRK1B0.0139.5
0.0529.5
0.1036.5
0.2541.0
0.5040.5
1.0065.5