Table 1.

Genes examined for synergy with ATRi

Gene nameFunctionPathway
PolADNA polymerase alpha, catalytic subunitDNA replication
PRIM1DNA primase, 49 kDaDNA replication
PolEDNA polymerase epsilon, catalytic subunitDNA replication
PolD1DNA polymerase delta, catalytic subunitDNA replication
RRM1Ribonucleotide reductase large subunitDNA synthesis
RRM2Ribonucleotide reductase small subunitDNA synthesis
Chk1Checkpoint kinase 1Replication, checkpoint, DNA damage and repair
Chk2Checkpoint kinase 2Checkpoint and DNA repair
ClspnClaspinCheckpoint, DNA damage and repair
ATMAtaxia telangiectasia mutatedPI3K–DNA damage, HR
DNA-PKcsDNA-dependent protein kinase catalytic subunitPI3K–DNA damage, NHEJ
Wee1Wee1 homolog (S. pombe)Replication, checkpoint, DNA damage
Cdk2Cyclin-dependent kinase 2Cell cycle (G1–S phase)
TopBP1Topoisomerase (DNA) II binding protein 1Replication, checkpoint, DNA damage
BLMBloom syndrome, RecQ helicase-likeReplication and repair
BRCA1Breast cancer 1, early onsetDNA damage and repair
Cdc45Cell division cycle 45Initiation of DNA replication
Cdc6Cell division cycle 6Initiation of DNA replication
Cdc7Cell division cycle 7Replication and checkpoint

Table shows gene names, annotation of function, and pathway of genes used in the siRNA screen.