Table 1.

In vitro cytotoxicity values of ganetespib in bladder cancer cell lines

Cell lineGanetespib IC50 (nmol/L)FGFR3 Status
DSH16WT
SW-17106WT
T247WT
RT1129FGFR3-TACC3
639-V10R248C
SCaBER10WT
BFTC17WT
J8218K652E
HT-137621WT
647-V27WT
UM-UC333WT
LB831-BLC34WT
KU-19-1936WT
97-738S249C
563744WT
HT-119753WT
MGH-U353Y375C
TCCSUP142WT
RT41733FGFR3-TACC3
SW7803451FGFR3-BAIAP2L1