Table 5.

PI3K pathway mutations in HNSCC cell lines and tumors

Gene nameCell line/siteTumor/site
MTORBICR18/p.V1692AHN_62421/p.L2260H HN_62469/p.R1161Q
PIK3CACAL33/p.H1047R DETROIT562/p.H1047R HSC2/p.H1047R SNU1076/p.H1047RHN_62415/p.E545G HN_62426/p.E545K HN_62469/p.H1047R HN_62825/p.R115L HN_63027/p.E542K HN_63039/p.H1047L HN11PT/p.H1047R HN41PT/p.H1047L 325/p.H1047L
PIK3CDSNU1076/p.L558VHN_62672/p.T423S
PIK3CGCAL27/p.R178C SNU1041/p.A197T SNU899/p.R366G p.H577YHN_01000/p.R1021S HN_62532/p.L843H HN_62854/p.S446F
HN_63021/p.P526S HN22PT/p.G491E
PIK3C2ABICR6/p.M1577V YD38/p.A1649VHN_62699/c.e6_splice_site
PIK3C2BSNU899/p.R1610HHN_62739/p.R564C
PIK3C2GBHY/p.P129del BICR16/p.P129delHN_00190/p.V656L
BICR18/p.P129del BICR6/p.P129del
BICR56/p.H1304R DETROIT562/p.P129del
PECAPJ15/p.P129del PECAPJ49/p.P129del
PECAPJ41CLONED2/p.P129del
HSC2/p.P129del HSC4/p.P129del
SCC15/p.P129del SNU1041/p.K714N
SNU46/p.E1301D
YD8/p.P129del YD38/p.K70R YD38/p.P129del
PIK3R1HN_00361/p.453_454insN HN_62338/p.I290V HN_62421/p.D560H
PIK3R4BICR56/p.574_575ND>KY SCC25/p.E529_splice YD10B/p.A968D
PIK3R6HN_62860/p.R483H
PTENHSC4/p.C136W p.V343_spliceHN_00190/p.D92E HN_62652/c.e7_splice_site HN_62741/p.D252Y HN_62863/p.P246L HN_63039/p.R335*
PDK1BICR18/p.P283T
PIK3AP1HN_62506/p.A136D HN22PT/p.G313R 91/p.R478Q 266/p.T352S
PIK3C3SNU1066/p.R162K
TSC1HN_00761/p.R245*
TSC2PECAPJ49/p.R1268C