Table 1.

Verapamil and resveratrol enhanced ursolic acid-mediated cytotoxicity in MT1/2 cells, indicated by a decrease in the IC50 for ursolic acid (average of 3–4 independent experiments, n = 3/exp)

CompoundDoseFold decrease of IC50P
+Veh1
+5 μmol/L1.14 ± 0.16
Verapamil+10 μmol/L1.17 ± 0.19
+25 μmol/L1.53 ± 0.31
+50 μmol/L1.99 ± 0.41<0.01
+100 μmol/L2.52 ± 0.53<0.05
+Veh1
+5 μmol/L1.00 ± 0.02
Cyclosporin A+10 μmol/L1.03 ± 0.11
+25 μmol/L1.13 ± 0.11
+50 μmol/L1.25 ± 0.27
+100 μmol/L1.24 ± 0.23
+Veh1
+5 μmol/L1.01 ± 0.06
Resveratrol+10 μmol/L1.01 ± 0.07
+25 μmol/L1.38 ± 0.2<0.05
+50 μmol/L1.35 ± 0.17<0.05
+100 μmol/L1.3 ± 0.11<0.005

NOTE: The cytotoxicity of ursolic acid was enhanced by verapamil and resveratrol in MT1/2 cells.