Table 1.

Identification of tumor-derived mutations in B56γ

Amino acid (protein)IsoformsOriginHEAT-repeatReference
C39Rγ1, 2, 3Pooled glandular1(17)
A61Vγ1, 2, 3Pooled glandular1This study
L157Pγ1, 2, 3Pooled glandular3
E164Kγ1, 2, 3Pooled glandular3This study
R169Kγ1, 2, 3Pooled glandular3
A212Tγ1, 2, 3Melanotic melanoma skin4This study
S220Nγ1, 2, 3Leiomyosarcoma uterus4This study
H233Pγ1, 2, 3Embryonal carcinoma5
S251Rγ1, 2, 3Embryonal carcinoma5This study
Q256Rγ1, 2, 3Melanotic melanoma skin5This study
L257Rγ1, 2, 3Melanotic melanoma skin5This study
L265Fγ1, 2, 3Embryonal carcinoma5
E266Rγ1, 2, 3Embryonal carcinoma5This study
P274Tγ1, 2, 3Large cell carcinoma lung6This study
H287Qγ1, 2, 3Pooled glandular6This study
P289Sγ1, 2, 3Pooled glandular6This study
A383Gγ1, 2, 3Ilea mucosa8(14)
F395Cγ1, 2, 3Lung carcinoma9(14)
Q401Rγ1, 2, 3Pooled germ cell tumor9
E409Rγ1, 2, 3Pooled germ cell tumor9
K410Rγ1, 2, 3Pooled germ cell tumor9
S440Iγ1, 2, 3Lung carcinoma
H494Pγ2, 3Embryonal carcinoma
T495Hγ2, 3Embryonal carcinoma

NOTE: Different tumor-derived B56γ mutations shown with the mutated residue (column 1), applicable B56γ isoforms (column 2), tumor origin of the mutation (column 3), location on the B56γ protein (column 5), and reference (column 6).