Table 2.

Characterization of 14 tumor-derived B56γ mutations

InteractionCell growth inhibition
B56γ3PP2A AC corep53p53 Thr55 Dephosphorylationp21 Inductionp53 Dependentp53 Independent
WTYYYYYY
C39RNYNNNN
A61VYYYYYY
E164KNYNNNN
A212TYYYYYY
S220NYYYYYN
S251RYYYYYY
Q256RNYNNNN
L257RNYNNNN
E266RYYYYYY
P274TYYYYYY
H287QYYYYYY
P289SYYYYYY
A383GYNNNNY
F395CYNNNNY

NOTE: Summary of 14 tumor-derived B56γ mutations' tumor-suppressive functional assays that shows interaction of B56γ with PP2A AC core or p53 (column 2 or 3), dephosphorylation of p53 at Thr55 (column 4), induction of p21 (column 5), and effects on cell growth in p53-dependent or p53-independent manner (column 6 or 7).

Abbreviations: Y, Inhibition of cell growth; N, No inhibition on cell growth.