Table 1.

Signaling proteins included in signaling module scores

IntegrinIGF-1RApoptosismTORAKTEGFR
Src family (Y416)IGF-1R (Y1135/1136)/Insulin Receptor (Y1150/1151)BADmTOR (S2448)PDK1 (S241)EGFR (Y1148)
FAK (Y576/577)IGF-1R (Y1131)/Insulin Receptor (Y1146)BAXmTOR (S2481)AKT (S473)EGFR (Y845)
FAK (Y397)IRS-1 (S612)Smac/diablo4E-BP1 (S65)AKT (T308)EGFR (Y1173)
Paxillin (Y118)SHC (Y317)XIAP4E-BP1 (T70)GSK3α/β (S21/9)Ras-GRF1 (S916)
Cofilin (S3)GAB1 (Y627)Cleaved Caspase-9 (D315)eIF4E (S209)PRAS40 (T246)AKT (S473)
CrkII (Y221)SHP2 (Y580)Cleaved Caspase-9 (D330)eIF4G (S1108)Tuberin/TSC2 (Y1571)AKT (T308)
Cleaved Caspase-3 (D175)p70S6K (T389)SHC (Y317)
p70S6K (T412)C-Raf (S338)
p70S6K (S371)C-Raf (S259)
S6 Ribosomal Protein (S240/244)B-Raf (S445)
A-Raf (S299)
MEK1/2 (S217/221)
ERK1/2 (T202/Y204)
p90RSK (S380)