Table 6.

Docking scores of crizotinib and NVP-TAE684 on human WT and L1196Q ALK

WT-ALK (PDB 2XP2)WT-ALK (PDB 2XB7)L1196Q-ALK (Q-R1)L1196Q-ALK (Q-R2)
Crizotinib7.16-ND6.73
NVP-TAE684-5.674.475.63

Abbreviation: ND, not defined.