Table 1.

Histology, mutation status, and PTEN expression of 13 NSCLC lung cancer cell lines with high pAKT(S473) under serum starvation conditions

HistologyPTEN mutationPIK3CA mutationKRAS mutationEGFR mutationOtherPTEN expressiona
Calu-3AdenocarcinomaWTWTWTWTHER2 CN gain (50)
H157SquamousG251C (38)WTG12R (4)WTLKB1 LOH (51)None
H820AdenocarcinomaN/AWTWTE746_T751del, I ins; T790M (4)
H1650Adenocarcinoma, BronchoalveolarN/AWTWTE746_A750del (4)None
H1781BronchoalveolarN/AWTWTWTHER2_G776insV (4)None
H1819AdenocarcinomaWTWTWTWTHER2 CN gain (50)
H2444NSCLCN/AWTG12V (4)WTNone
H3255AdenocarcinomaN/AWTWTL858R (4)
HCC461AdenocarcinomaN/AWTG12D (4)WTNone
HCC2429NSCLCN/AWTWTWT
HCC2450SquamousN/AH1047R (4)WTWT
HCC2935AdenocarcinomaN/AWTWTE746_A750del, T751A (4)None
PC9AdenocarcinomaWTWTWTE746_A750del (4)

Abbreviations: CN, copy number; N/A, not available; WT, wild-type.

  • aObservations made here (Fig. 1).