Table 5.

IC50 values, expressed in ╬╝mol/L, obtained for each Ba/F3 cell line and relative therapeutic index (TI) calculated as IC50 parental line/IC50 mutant, are summarized

CRIZOTINIBAP26113NVP-TAE684
IC50NormT.I.IC50NormT.I.IC50NormT.I.
Ba/F31.26136.0901.0000.82078.0211.0000.760127.3891.000
Ba/F3 NA WT0.0351.00036.0900.0111.00078.0210.0061.000127.389
Ba/F3 L1196Q0.2126.0765.9400.0090.85691.1110.0091.50984.444
Ba/F3 I1171N0.2156.1565.8620.32931.2562.4960.759127.2541.001
Ba/F3 L1196M0.45913.1252.7500.0423.98319.5890.0183.02242.152

NOTE: IC50 values obtained derive from at least 2 independent experiments.