All mutations identified, corresponding substitutions and relative frequencies are presented
| Cell line | Dose (μmol/L) | Mutation | Substitution | Frequency (%) |
|---|---|---|---|---|
| K299 | 0.1 μmol/L | 4539T→A | L1196Q | 12.5 |
| 4485A→G | N1178S | 3 | ||
| 4596C→T | P1215L | 3 | ||
| 4936G→A | M1328I | 3 | ||
| 0.3 μmol/L | 4539T→A | L1196Q | 83.8 | |
| 4521T→C | L1190P | 2.7 | ||
| 0.6 μmol/L | 4539T→A | L1196Q | 85.7 | |
| 1 μmol/L | 4539T→A | L1196Q | 58 | |
| SUP-M2 | 0.2 μmol/L | 4464–65TC→AT | I1171N | 50 |
| 0.3 μmol/L | 4464–65TC→AT | I1171N | 100 |