Table 3.

All mutations identified, corresponding substitutions and relative frequencies are presented

Cell lineDose (μmol/L)MutationSubstitutionFrequency (%)
K2990.1 μmol/L4539T→AL1196Q12.5
4485A→GN1178S3
4596C→TP1215L3
4936G→AM1328I3
0.3 μmol/L4539T→AL1196Q83.8
4521T→CL1190P2.7
0.6 μmol/L4539T→AL1196Q85.7
1 μmol/L4539T→AL1196Q58
SUP-M20.2 μmol/L4464–65TC→ATI1171N50
0.3 μmol/L4464–65TC→ATI1171N100