Table 2.

Gene-set enrichment analysis for differentially expressed mRNAs in more versus less sensitive PDA cell lines

Gene ontology processCanonical nameEnrichment
Sensitive cell linesa
 Downregulated Genes
  GO:0006260DNA replication1.02E-11
  GO:0006259DNA metabolic process5.89E-11
  GO:0006270DNA replication initiation5.48E-10
  GO:0007049Cell cycle1.44E-08
  GO:0006261DNA-dependent DNA replication2.62E-08
  GO:0022402Cell-cycle process2.37E-06
  GO:0022403Cell-cycle phase2.47E-06
  GO:0051301Cell division1.68E-05
  GO:0000279M phase4.79E-05
  GO:0000278Mitotic cell cycle1.70E-04
 Upregulated genes
  GO:0009605Response to external stimulus2.13E-06
  GO:0009611Response to wounding3.25E-06
  GO:0006954Inflammatory response1.33E-05
  GO:0006952Defense response6.32E-05
  GO:0048583Regulation of response to stimulus1.84E-04
  GO:0031667Response to nutrient levels2.32E-04
  GO:0007584Response to nutrient2.44E-04
  GO:0008285Negative regulation of cell proliferation3.72E-04
  GO:0050776Regulation of immune response4.66E-04
  GO:0009991Response to extracellular stimulus6.42E-04
  GO:0031347Regulation of defense response7.61E-04
  GO:0051187Cofactor catabolic process9.22E-04
Insensitive cell linesb
 Downregulated Genes
  GO:0010647Positive regulation of cell communication3.39E-04
 Upregulated Genes
  GO:0008285Negative regulation of cell proliferation3.07E-04
  • aGene Ontology processes enrichment analysis for differentially expressed mRNAs in sensitive PDA cell lines (P ≤ 0.05).

  • bEnrichment analysis for differentially expressed mRNAs in less sensitive PDA cell lines (P ≤ 0.05).