Table 1.

Gene-set enrichment analysis for mRNAs positively or negatively correlated with GI50

MSigDB C2: KEGG-insensitive cell linesaNeighborsEnrichment
 HSA00562_INOSITOL_PHOSPHATE_METABOLISM61.36E-03
 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM73.83E-03
 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON129.65E-03
 HSA04370_VEGF_SIGNALING_PATHWAY61.22E-02
 HSA04910_INSULIN_SIGNALING_PATHWAY91.30E-02
 HSA04310_WNT_SIGNALING_PATHWAY91.43E-02
 HSA04530_TIGHT_JUNCTION82.16E-02
 HSA04330_NOTCH_SIGNALING_PATHWAY42.30E-02
 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY72.46E-02
 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY52.98E-02
 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION73.13E-02
 HSA04012_ERBB_SIGNALING_PATHWAY63.24E-02
 HSA00310_LYSINE_DEGRADATION43.47E-02
 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY64.79E-02
MSigDB C2: KEGG-sensitive cell linesbNeighborsEnrichment
 HSA03010_RIBOSOME448.60E-47
 HSA00190_OXIDATIVE_PHOSPHORYLATION322.81E-21
 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS61.71E-03
 HSA00620_PYRUVATE_METABOLISM62.32E-03
 HSA00230_PURINE_METABOLISM122.63E-03
 HSA03020_RNA_POLYMERASE44.35E-03
 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION47.76E-03
 HSA00240_PYRIMIDINE_METABOLISM71.80E-02
  • aMSig DB enrichment analysis for mRNAs positively correlated with GI50 (P ≤ 0.05).

  • bEnrichment analysis for mRNAs negatively correlated with GI50 (P ≤ 0.05).