Table 2.

Sensitizing DNA glycosylases and their known substrates

Gene symbolGene nameKnown substrateaScreen viability ratio
OGG18-oxoguanine DNA glycosylase8-oxoG:C = T = G; me-FapyG:C; FapyG:C; 8-oxoA:C; urea0.648
UNGUracil DNA glycosylasessU; U:G; U:A; 5-fluorouracil; 5,6-Dihydroxy-U:G; 5-OH-U:G; Isodialuric acid; Alloxan0.446
TDGThymine DNA glycosylaseU:G; T:G and ethenoC:G; 5-Fluorouracil; 5-fluorouracil (ss); 5-Hydroxymethyluracil; hypoxanthine:G; 5-bromouracil; εC:ATg:G; 5-formyl-U0.541
NEIL1Nei endonuclease VIII-like 1 (E. coli)TgG; 5-OH-C; 5-OH-U:AT>G; Guanidinohydantoin; guanidinohydantoin (ss); Iminoallantoin; Iminoallantoin (ss); Spiroiminodihydantoin; Spiroiminodihydantoin (ss);5,6-Dihydro-T; 5,6-Dihydro-U:G = C = A>T; FapyG:C;8-Oxo-G:C = G>T>A; FapyA:T; (5′R)-8,5′-Cyclo-2′-deoxyadenosine; (5′S)-8,5′-Cyclo-2′-deoxyadenosine; 8-Oxo-A:C0.559
  • aFor mismatched base pairs, the repaired or removed base is configured on the left in each case.