Table 1.

Significantly altered genes upon AEBP1 silencing

Gene symbolGene IDRegulationFold changeP-valueFunction
AREG374Up5.750.00034Cell proliferation
BLZF18548Up3.170.037Cell proliferation
USP89101Up2.650.028Cell proliferation
ELF52001Up2.160.036Cell proliferation
TNFSF148740Up4.060.026Cell proliferation, regulation of apoptosis
PDGFB5155Up5.380.01Cell proliferation, regulation of cell migration
CDKN2C1031Up4.700.02Cell cycle, regulation of apoptosis
SCIN85477Up3.110.04Regulation of apoptosis
MX14599Up2.450.002Regulation of apoptosis
EDN11906Up6.860.04Regulation of cell migration
APOH350Up6.150.019Regulation of cell migration
LAMA43910Up5.050.004Regulation of cell migration
PARD6B84612Up3.540.019Regulation of cell migration
EGFR*1956Up1.510.01Cell proliferation
MDM2*4193Up2.630.04Cell cycle, apoptosis
RAB54B25788Down−2.930.001Cell cycle
UBC7316Down−2.340.03Cell cycle
FBXO526271Down−2.220.03Cell cycle
HDAC610013Down−2.220.04Cell Cycle
SMC1A8243Down−2.100.02Cell cycle
KIF2C11004Down−2.700.001Cell cycle, cell proliferation
E2F11869Down−2.130.01Cell cycle, cell proliferation, apoptosis
E2F21870Down−2.610.04Cell cycle, apoptosis
CDC25C995Down−2.110.01Cell cycle, cell proliferation
DLG11739Down−2.200.003Cell proliferation
IFNB13456Down−2.190.02Cell proliferation
ZMYND1110771Down−2.140.004Cell proliferation
EPS152060Down−2.070.03Cell proliferation
B2M*567Down−1.560.008Immune response
TEGT*7009Down−1.90.001Regulation of apoptosis
UACA*55075Down−2.80.01Regulation of apoptosis
CAMK2D**817Down−1.690.001Regulation of cell growth

* Denotes perturbed gene in primary GBM (9)

** Denotes perturbed gene in secondary GBM (9)