Table 2.

IGF1R knockdown impairs KRASG12D- and BRAFV600E-induced pancreatic tumorigenesis

Cells implantedTumor incidenceTime to tumor development (wks)Average tumor volume (SEM)
KRASG12D control4/57576 mm3 (±436)
KRASG12D IGF1R shRNA0/67N/A
BRAFV600E control6/671211 mm3 (±239)
BRAFV600E IGF1R shRNA5/6772 mm3 (±20)

NOTE: Tumor volume calculated using the formula L × W × H.