Table 1.

Gene products whose silencing resulted in greater than 50% cell death in the presence of 90 ╬╝mol/L imexon (IC10)

Gene symbolGene namesiRNA (% survival)siRNA + imexon (% survival)Ratio siRNA + imexon siRNA
EIF2B5eIF 2B, subunit 578.227.735.4
SLC9A3R2Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 253.719.436.0
ARHGAP26Rho GTPase activating protein 2673.131.042.5
SERPINC1Serpin peptidase inhibitor, clade C, member 185.936.642.6
OR2AE1Olfactory receptor, family 2, subfamily AE, member 1101.743.442.7
ARHGEF5Rho GEF 589.238.843.8
KDRKinase insert domain receptor87.538.143.5
SERPINE1Serpin peptidase inhibitor, clade E, member 166.128.843.5
SETSET nuclear oncogene82.436.243.9
OR1L1Olfactory receptor, family 1, subfamily L, member 1105.747.244.7
SERPINE2Serpin peptidase inhibitor, clade E, member 255.125.245.7
FBX08F-box protein 865.430.146.0
ZNF200Zinc finger protein 200102.247.246.2
SP7Sp7 transcription factor36.517.046.7
ZFP36L1Zinc finger protein 36, C3H type-like 176.836.046.9
OR51G2Olfactory receptor, family 51, subfamily G, member 285.140.447.5
WASH1WAS protein family homolog 190.743.748.2
MANFMesencephalic astrocyte-derived neurotrophic factor60.029.449.0
CYTH1Cytohesin 155.127.349.6
MRLP10Mitochondrial ribosomal protein L1065.432.549.8