Table 1.

PKD1 expression and its roles in various cancers

No.Cancer typePKD1 statusModulated signaling pathwayReference
1Breast cancerDownregulatedMMPsEisler et al (52)
Actin remodeling and cell motilityPeterburs et al (54)
EMTDu et al (65)
2Prostate cancerContentiousE-cadherin/β-cateninJaggi et al (40, 42)
DownregulatedAR signalingMak et al (37)
HSP27Hassan et al (38)
EMTDu et al (65)
ERK/MAPK/MMPsBiswas et al (66)
UpregulatedChen et al (70)
3Gastrointestinal cancerDownregulatedβ-cateninKim et al (59)
Cox-2Jepperson et al (60)
Rodriguez Perez et al (72)
4Pancreatic cancerUpregulatedRas/Raf/MEK/ERK/RSKGuha et al (61, 73)
HSP27Yuan et al (78)
EGF/JNKKisfavli et al (33)
ApoptosisTrauzold et al (32)
5Basal cell cancerUpregulatedRistich et al (63)
ERK/MAPKJadali et al (75)
ApoptosisArun et al (76)