Table 3.

SAM analysis was conducted on microarray data

Gene IDSymbolGene descriptionFold changeq (%)
228729 atCCNB1Cyclin B19.913.85
228069 atFAM54AFamily with sequence similarity 54, member A9.303.85
203362 s atMAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)5.440.00
209408 atKIF2CKinesin family member 2C5.033.85
218009 s atPRC1Protein regulator of cytokinesis 14.990.00
218875 s atFBXO5F-box protein 54.953.85
219148 atPBKPDZ-binding kinase4.850.00
219918 s atASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)4.443.85
203213 atCDK1Cyclin-dependent kinase 14.133.85
214710 s atCCNB1Cyclin B13.880.00
208808 s atHMGB2High-mobility group box 23.810.00
208079 s atAURKAAurora kinase A3.550.00

NOTE: SAM identifies 12 genes that are statistically upregulated in both tumor and TAHN-1 cells with the highest hTERT promoter activity. “Telomerase high” data sets from both tumor and TAHN-1 were compared with “telomerase low” data sets from tumor and TAHN-1 in a paired analysis. The arrays were median centered, a minimum fold change of 3 was set, and a delta value of 6.23 was set to establish a false discovery rate of 3.85% (q value). Using these values, 12 genes were identified that were statistically significantly overexpressed in the cells with high telomerase promoter activity in both tumor and TAHN-1 cells. No genes were found to be significantly underexpressed in these cells.