Table 2.

Component gene lists from enriched pathways from Fig. 6

Pathway genes from 140 AS gene list
Pathway nameComponent genes from Pathway
Axonal guidance signalingPTK2, SLIT3, PRKACB, GNAS, ADAM15, ITGA2, ITGA5, LIMK2, RASSF5, SEMA4A
Integrin signalingPTK2, DDEF1, ITGA2, ITGA6, ITGA5, ACTN1
Actin cytoskeleton signalingPTK2, TIAM1, ITGA2, ITGA5, LIMK2, ACTN1
Tight junction signalingPRKACB, EPB41, TIAM1, TJP3, TJP1
PTEN signalingPTK2, ITGA2, ITGA5
Androgen and estrogen metabolismSTS
NF-κB signalingPRKACB
Ephrin receptor signalingPTK2, GNAS, GRIN2D, ITGA2, ITGA5, LIMK2
ERK/MAPK signalingPTK2, PRKACB, ITGA2, ITGA5
Xenobiotic metabolism signalingGSTM1, GSTP1, ALDH3A2, SULT1A1
Metabolism of xenobiotics by cytochrome P450GSTM1, GSTP1
Pathway genes from 222 DE gene list
Pathway nameComponent genes from Pathway
Axonal guidance signalingSEMA3A, SEMA3D, PIK3C2G, AKT3, EPHA3, BMP5, ITGA4
Ephrin receptor signalingPIK3C2G, AKT3, EPHA3, ITGA4
Integrin signalingPIK3C2G, AKT3, ITGB6, ITGA4
Actin cytoskeleton signalingFGF2, PIK3C2G, ITGA4, MSN
PTEN signalingGHR, AKT3, ITGA4
ERK/MAPK signalingPLA2G4A, PIK3C2G, ELF5, ITGA4
Xenobiotic metabolism signalingIL1A, CAMK4, ALDH1A1, UGT2B4, PIK3C2G, IL1B, SULT1E1, SULT1B1, UGT2B28
Metabolism of xenobiotics by cytochrome p450AKR1C1, UGT2B4, DHRS2, CYP4F11, UGT2B28
Androgen and estrogen metabolismAKR1C1, UGT2B4, SULT1E1, HSD17B2, UGT2B28
NF-κB signalingIL18, IL1A, GHR, PIK3C2G, IL1B, AKT3
Wnt/β-catenin signalingCDH2, MMP7, GJA1, SFRP2, AKT3, SFRP1, DKK1
p53 signalingCCND2, PIK3C2G, AKT3, SERPINB5
FXR/RXR activationIL18, IL1A, UGT2B4, IL1B, AKT3
Tyrosine metabolismTYRP1, DHRS2 (includes EG:10202), TYR, DCT
Retinol metabolismALDH1A1, UGT2B4, UGT2B28
Pentose and glucuronate interconversionsUCHL1, UGT2B4, UGT2B28