Table 3.

Diagnostic performance of modelnormRE, modelnormGO, and modelRRnormRE in different patient groups versus the normal female training set

ModelnormGO
Patient groupC value*SpecificitySensitivitySensitivity (Spec. 97.5)Maximum accuracy
Stage II to IV0.94 (0.80-0.99)0.900.930.610.91
Stage I0.90 (0.62-0.97)0.940.800.500.92
Stage I to IV0.93 (0.80-0.98)0.880.890.580.89
ModelnormRE
Patient groupC valueSpecificitySensitivitySensitivity (Spec. 97.5)Maximum accuracy
Stage II to IV0.89 (0.74-0.96)0.920.790.570.88
Stage I0.94 (0.76-0.99)0.920.900.700.95
Stage I to IV0.91 (0.78-0.97)0.920.820.500.89
ModelRRnormRE
Patient groupC valueSpecificitySensitivitySensitivity (Spec. 97.5)Maximum accuracy
Stage II to IV0.90 (0.76-0.97)0.820.820.570.84
Stage I0.97 (0.89-1.00)0.871.000.700.95
Stage I to IV0.92 (0.81-0.97)0.820.870.500.85

NOTE: Model performance was assessed by calculating the area under the ROC curve.

  • *C value (area under the ROC curve with 95% confidence intervals in brackets).

  • Specificity and sensitivity were calculated at the point of best separation.

  • Sensitivity at a specificity of 97.5%.