Table 1.

Representative BPDE-Induced Cytotoxicity and Mutagenicity Data for Primary Dermal Fibroblasts Derived from A/J Mice

Cell LineREV1 Expression (%)BPDE (μmol/L)% Survival6-Thioguanine-resistant ClonesNo. Cells Selected × 10−6Mutants/106 Clonable Cells*
B-1100010001<10
0.1536862195
B-215010001<10
0.152812223
  • * Corrected for cloning efficiency on the day of selection (B-1, 22%; B-2, 26%).