Table 1.

Summary of Melanoma Samples Carrying FGFR2 Mutations

SamplesNucleotide ChangeCodon ChangeBRAFNRAS
Cell Lines
    MM540G812AG271EV600Ewt
    UACC1940G913AG305Rwtwt
    WSBC1109GT370R*V600Ewt
    M92-001G1423AE475K*wtG13R
    ME10538G1423AE475KV600Ewt
    M91-054T2308GL770VV600Ewt
    UACC2534G752AR251Qwtwt
    A375G1906AE636K*V600Ewt
    UACC3093GG2100-1AAG701SwtQ61L
    D11G1920AM640IwtQ61L
    MM369G655AE219KV600Ewt
    D22G1588AD530Nwtwt
    D22C2275TR759Xwtwt
    MM229G2276AR759QL597Swt
    A04G1942AA648T*wtwt
    A05A479CE160AV600Ewt
Metastatic Tumors
    Met19G680AG227Ewtnd
    Met27C71TS24Fndnd
    Met15G229A G1720A C2063T C2122TV77M E574K S688F P708SV600End
Primary Tumors
    81IVS15-2A>T§FSV600Ewt
    AM169T743AV248Dwtwt
    AM146C637TH213YwtQ61L
    53**G1422AW474Xwtwt
    71**G1924AI642Vwtwt
  • Abbreviations: wt, wild type; nd, not done.

  • * Samples were homozygous for this mutation.

  • Microsatellite genotyping confirmed that these cell lines were independent.

  • Superficial spreading primary melanoma, no chronic sun damage evident.

  • § The IVS15_2A>T is predicted to result in the skipping of exon 16, subsequent frameshift for 27 amino acids, and a premature truncation at codon 690 in the kinase domain.

  • Acral melanoma, histologically superficial spreading melanoma.

  • Mucosal primary melanoma.

  • ** Primary Lentigo Maligna Melanoma, with histologic evidence of chronic sun damage.