TABLE 1.

IC50 of Benzimidazole Compounds That Display Melanoma-Specific (M-14 and SK-Mel-19) Growth Inhibition as Compared with Melanocytes (Melan-a)

Melan-aSK-Mel-19M-14
Mebendazole1.9 μmol/L (0.05)0.3 μmol/L (0.1)0.32 μmol/L (0.2)
Albendazole3.8 μmol/L (0.3)0.7 μmol/L (0.07)1.2 μmol/L (0.1)
Fenbendazole3.4 μmol/L (0.2)1.2 μmol/L (0.3)1.4 μmol/L (0.4)
Oxybendazole3.5 μmol/L (0.1)0.8 μmol/L (0.05)1.1 μmol/L (0.2)
  • NOTE: Cellular proliferation was determined using the CellTiter 96 AQueous Non-Radioactive Cell Proliferation Assay. Each data point is derived from a minimum of four independent experiments. Error bars represent SE.