Table 1.

Selective In vitro Micromolar Activity (IC50) of Inhibitors Against Deacetylase Activity of Affinity-Purified FLAG-tagged HDAC1 and HDAC6 Subtypes, Measured as Described in Materials and Methods

HDAC1 (IC50)HDAC5 (IC50)Selectivity for HDAC6
ST1722.86 ± 7.251.69 ± 0.9113.5
ST8028.61 ± 2.530.91 ± 0.4431.4
ST7182.60 ± 4.964.01 ± 1.6120.6